Home >> Antibodies >> Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)

Cyclin D1 (G1-Cyclin & Mantle Cell Lymphoma Marker)

Recombinant Mouse Monoclonal Antibody [Clone rCCND1/4752]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained Cyclin D1 Recombinant Mouse Monoclonal Antibody (rCCND1/4752).

SDS-PAGE Analysis Purified Cyclin D1 Recombinant Mouse Monoclonal Antibody (rCCND1/4752). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human mantle cell lymphoma stained Cyclin D1 Recombinant Mouse Monoclonal Antibody (rCCND1/4752).

SDS-PAGE Analysis Purified Cyclin D1 Recombinant Mouse Monoclonal Antibody (rCCND1/4752). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

B cell CLL/lymphoma 1; B cell leukemia 1; B-cell lymphoma 1 protein; BCL-1 oncogene; CCND1 protein; CCND1/FSTL3 fusion gene; CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene; CCND1/PTH fusion gene; G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene

Positive Control

Human mantle cell lymphoma, breast or bladder carcinomas.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Synthetic peptide corresponding to residues within aa 200-295 of Cyclin D1

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

36kDa

Specificity & Comments

Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.