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SDS-PAGE Analysis Purified CD8A Mouse Monoclonal Antibody (RIV11). Confirmation of Integrity and Purity of Antibody.
Immunofluorescence staining of human PBMC cells. CD8A Mouse Monoclonal Antibody (RIV11) followed by goat anti-mouse IgG-CF488 (green).
Flow Cytometric Analysis of human PBMC cells. CD8A Mouse Monoclonal Antibody (RIV11) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated and subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8 interacts with the 3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the chain recruits the tyrosine kinase Lck, which is essential for T cell activation.
Key References
