Formalin-fixed, paraffin-embedded human tonsil stained with CD6 Recombinant Rabbit Monoclonal Antibody (C6/7022R).
IHC analysis of formalin-fixed, paraffin-embedded human spleen. Staining using C6/7022R at 2ug/ml in PBS for 30min RT. Inset: PBS instead of primary antibody; secondary only negative control.
SDS-PAGE Analysis Purified CD6 Rabbit Recombinant Monoclonal Antibody (C6/7022R). Confirmation of Purity and Integrity of Antibody.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.