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Formalin-fixed, paraffin-embedded Human Lymph Node stained with CD45 Rabbit Recombinant Monoclonal Antibody (PTPRC/1975R).
SDS-PAGE Analysis Purified CD45 Rabbit Recombinant Monoclonal Antibody (PTPRC/1975R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Human spleen tissue lysate using CD45 Rabbit Recombinant Monoclonal Antibody (PTPRC/1975R).
Flow Cytometric Analysis of paraformaldehyde-fixed Raji cells using CD45 Rabbit Recombinant Monoclonal Antibody (PTPRC/1975R) followed by Goat anti-rabbit IgG-CF488 (Blue); Isotype Control (Red).
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.
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