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Home >> Antibodies >> Cathepsin D (Tumor Marker)

Cathepsin D (Tumor Marker)

Mouse Monoclonal Antibody [Clone CTSD/4497]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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Formalin-fixed, paraffin-embedded human liver carcinoma in colonstained with Cathepsin DMouse Monoclonal Antibody (CTSD/4497).

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Formalin-fixed, paraffin-embedded human liver stained with Cathepsin D Mouse Monoclonal Antibody (CTSD/4497).

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Formalin-fixed, paraffin-embedded human pancreas stained with Cathepsin D Mouse Monoclonal Antibody (CTSD/4497).

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SDS-PAGE Analysis Purified Cathepsin D Mouse Monoclonal Antibody (CTSD/4497). Confirmation of Purity and Integrity of Antibody.

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Western blot analysis of human livertissue lysate using Cathepsin D Mouse Monoclonal Antibody (CTSD/4497).

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Analysis of Protein Array containing more than 19,000 full-length human proteins using Cathepsin D Mouse Monoclonal Antibody (CTSD/4497).

Product Details

Synonyms

CatD; Cathepsin D; Ceroid lipofuscinosis neuronal 10; CLN10; CPSD; Epididymis secretory sperm binding protein Li 130P; Lysosomal aspartyl peptidase; Lysosomal aspartyl protease

Positive Control

MCF-7, A431 or SK-BR3 cells. Kidney, liver, lung or breast.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Purified His-tagged CTSD protein

Cellular Localization

Cytoplasm

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

48kDa (Procathepsin D); 43kDa (preprocathepsin D); 34kDa (Cathepsin D); 28kDa (heavy chain); 15kDa (light chain)

Specificity & Comments

Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43kDa preprocathepsin D that is cleaved and glycosylated to form a 46kDa procathepsin D and then further cleaved to produce 28kDa and 15kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

Related Products



200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Nomura T,et al. J Med Invest.2005 Feb;52(1-2):1-9.

Bioinformatics

  •  Entrez Gene ID: 1509
  •  Gene Symbol: CTSD
  •  SwissProt: P07339
  •  Chromosome Location: 11p15.5
  •  Unigene: 654447