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Home >> Antibodies >> BRCA1 (Breast Marker)

BRCA1 (Breast Marker)

Mouse Monoclonal Antibody [Clone BRCA1/2985]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Analysis of Protein Array containing more than 19,000 full-length human proteins using BRCA-1 Mouse Monoclonal Antibody (BRCA1/2985)

Product Details

Synonyms

BRCA1; Breast and ovarian cancer susceptibility protein 1; Breast Cancer 1 Early Onset; Breast cancer type 1 susceptibility protein; BROVCA1; IRIS; PNCA4; PPP1R53; Protein phosphatase 1 regulatory subunit 53; PSCP; RING finger protein 53; RNF53

Positive Control

A431 or HeLa cells. Breast, Ovarian or Renal Cell Carcinoma.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating use Ab at 2-4ug/ml, order Ab without BSA), Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 445-620) of human BRCA1 protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic and Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

220kDa

Specificity & Comments

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Miki, Y., et al. 1994. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71.

Bioinformatics

  •  Entrez Gene ID: 672
  •  Gene Symbol: BRCA1
  •  SwissProt: P38398
  •  Chromosome Location: 17q21
  •  Unigene: 194143
NBT02985