Home >> Antibodies >> Blood Group Antigen H Type 2 (CD173)

Blood Group Antigen H Type 2 (CD173)

Mouse Monoclonal Antibody [Clone A51-B/A6]

Printable

Bioinformatics

Catalog #

Size

20 ug

100 ug

200 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

200 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Price (USD)

219.00

499.00

Printable

Bioinformatics

Product Details

Synonyms

A transferase; ABO; B transferase; CD173; Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-galactosyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase; Histo-blood group A transferase; Histo-blood group B transferase; NAGAT

Positive Control

KG1 cells or human colorectal carcinoma tissues.

Known Applications & Suggested Dilutions

IF, Immunohistology More Details

Immunofluorescence (2-4ug/ml)
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Immunogen

Human breast cancer MCF-7 cells

Cellular Localization

Cell Surface

Species Reactivity

Human. Others-not known.

Host / Ig Isotype

Mouse / IgA

Mol. Weight of Antigen

Multiple

Specificity & Comments

This antibody reacts with H type 2 blood group epitope Fuca1-2 Galb1-4 GlcNAc. It does not cross-react with human blood group H type 1, 3 or 4, nor with the closely related type 2 antigen Ley and Lex. Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. The A, B and H antigens are reported to undergo modulation during malignant cellular trans- formation. Blood group related antigens are usually mucin-type and are detected on erythrocytes, certain epithelial cells and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A (1 and 2), B, H (1 and 2), M, N, Lewis A, Lewis B, Lewis X, Lewis Y and precursor type 1 chain antigens. The expressions of the H1 and H2 in different cell types are con- trolled by different genes.