Formalin-fixed, paraffin-embeddedhuman Hepatocellular Carcinomastained with ARG1-MonospecificMouse Monoclonal Antibody (ARG1/1126).
SDS-PAGE Analysis Purified ARG1-MonospecificMouse Monoclonal Antibody (ARG1/1126). Confirmation of Integrity and Purity of Antibody.
Western Blot Analysis of Liver tissue lysate using ARG1Mouse Monoclonal Antibody (ARG1/1126).
Analysis of Protein Array containing more than 19,000 full-length human proteins using ARG1-MonospecificMouse Monoclonal Antibody (ARG1/1126).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes, which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.