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Recombinant TCL1 (T-Cell Marker) Antibody [TCL1/2747R]

In Stock
Catalog Number Formulation Size Price
8115-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
8115-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
8115-RBM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

T-cell leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (TPLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.13. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus
Gene Name
Positive Control
Ramos or Raji cells. Tonsil or T-cell Lymphoma.
Immunogen
Recombinant human TCL1 protein fragment (around aa 2-109) (exact sequence is proprietary)
Alternate Names
T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Protein p14 TCL1, TCL1A; Lymphoma/leukemia, T-cell; Oncogene TCL1; P14 TCL1; T cell leukemia 1; T cell lymphoma 1; T cell lymphoma 1A;T-cell leukemia/lymphoma 1A; TCL1; TCL1A

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
TCL1/2747R
Chromosome Location
14q32.13
Mol. Weight of Antigen
14kDa

Functions

  • Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

Key References

  • Narducci MG, et al. Cancer Res. 2000; 60:2095-100.
  • Roos J, et al. Pathobiology. 2001; 69:59-66.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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