Formalin-fixed, paraffin-embedded human Tonsil stained with TCL1 Recombinant Rabbit Monoclonal Antibody (TCL1/2747R).

SDS-PAGE Analysis Purified TCL1 Recombinant Rabbit Monoclonal Antibody (TCL1/2747R). Confirmation of Purity and Integrity of Antibody

TCL1 (T-Cell Marker) [TCL1/2747R]

Name: TCL1 (T-Cell Marker)
SKU: 8115-RBM3
Availability: InStock

Monoclonals Primary Antibodies Rabbit Monoclonals Recombinant Rabbit Monoclonals Recombinants

Summary

T-cell leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (TPLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.13. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma.

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Product Properties & Targets

Host

Rabbit

Species Reactivity

Human

Isotype

IgG

Cellular Localization

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

Gene Name

TCL1A

Mol. Weight of Antigen

14kDa

Immunogen

Recombinant human TCL1 protein fragment (around aa 2-109) (exact sequence is proprietary)

Database Links

Entrez Gene ID

10232

Unigene

2484

SwissProt

P56279

Additional Information

Clone

TCL1/2747R

Human Gene Symbol

TCL1A

Chromosome Location

14q32.13

Known Applications & Suggested Dilutions

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Key References

Narducci MG, et al. Cancer Res. 2000; 60:2095-100.
Roos J, et al. Pathobiology. 2001; 69:59-66.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.