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Small Cell Lung Carcinoma Antigen (SCLC Marker) Antibody [MOC-52]

In Stock
Catalog Number Formulation Size Price
MSM2-329-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MSM2-329-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MSM2-329-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

This MAb reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including small cell lung cancer (SCLC). It stains neural and a variable number of endocrine tissues and in the lung it reacts preferentially with SCLC and carcinoids. Its epitope is destroyed during formalin fixation. This antibody was categorized during the First International Workshop on Small Cell Lung Cancer Antigens held in London in April 1987. There are two major types of Lung Carcinoma: non-small cell, which accounts for 80% of all cases; and small cell, which accounts for roughly 20% of all lung cancers reported. The lung continues to be a customary place for cancer migration from tumors elsewhere in the body. Treatment depends on the specific cell type of the cancer, level of progression and status of the individual patient.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
N/A
Gene Name
N/A
Positive Control
adrenal gland., Human small cell lung carcinoma
Immunogen
Lung Cancer-associated antigen isolated from small cell lung carcinoma-derived cell line
Alternate Names
N/A, N/A, Not Known

Database Links

Entrez Gene ID
SwissProt
N/A

Additional Information

Clone
MOC-52
Chromosome Location
Not Known
Mol. Weight of Antigen
145kDa

Functions

  • N/A

Key References

  • W.H.O., 1982, 2nd ed. Am J. Clin. Path. 77, 123-136.
  • De Leij, L., et al., 1984, Eur. J. Canc. Clin. Oncol. 20, 123-128.
  • Souhami, R.L., et al., 1987, Lancet ii, 325-326.
  • De Leij, L., et al., 1987, In: Application of Monoclonal antibodies in tumor pathology (Ruiter DJ et al., eds), Dordrecht: Martinus Nijhoff, pp 191-210.
  • Berendsen, H.H., de Leij, L., Postmus, P.E., Ter Haar, J.G., Poppema, S. and The, T.H. 1988. Detection of small cell lung cancer metastases in bone marrow aspirates using monoclonal antibody directed against neuroendocrine differentiation antigen. J. Clin. Pathol. 41: 273-276.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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