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Major Vault Protein (MVP) Antibody [1014]

Additional information

Catalog Number: 9961-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
9961-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
9961-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
9961-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Major Vault Protein (MVP) Antibody

Western Blot Analysis of human HeLa cell lysate using Major Vault Protein (MVP) Mouse Monoclonal Antibody (Clone 1014).

Major Vault Protein (MVP) Antibody - Image 2

Immunofluorescence Analysis of A549 cells labeling MVP with MVP Monoclonal Antibody (Clone 1014) followed by Goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red).

Major Vault Protein (MVP) Antibody - Image 3

SDS-PAGE Analysis of Purified MVP Monoclonal Antibody (Clone 1014). Confirmation of Purity and Integrity of Antibody.

Major Vault Protein (MVP) Antibody in Western Blot (WB)

Major Vault Protein (MVP) Antibody in Western Blot (WB)

Western Blot Analysis of A549 lysate using Major Vault Protein (MVP) Mouse Monoclonal Antibody (Clone 1014).

  • Flow
  • IF
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Western Blot
Species Reactivity
Human
Clone
1014
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, Nuclear pore complex, Nucleus, Perinuclear region
Gene Name
MVP
Positive Control
A549, MCF-7 or HeLa cells. Breast tumors.
Immunogen
proteins precipitated from human breast cancer MCF-7 cells
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
Key References
  • Abbondanza C., et al. J Cell Biol 1998;141(6):1301-1310.
  • Den Boer, M.L. et al. Blood 91, 2092-2098 (1998).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
9961
SwissProt
Q14764
Chromosome Location
16p11.2
Mol. Weight of Antigen
104-110kDa
Alternate Names
Major vault protein, Lung resistance-related protein, Lung resistance-related protein (LRP); Major Vault Protein; MVP; VAULT1

Summary

Recognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for 70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.

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