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KIF2C (Kinesin Family Member 2C) / MCAK Antibody [KIF2C/4707]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
11004-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
11004-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
11004-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Kinesin family member 2c (KIF2C), alternately known as mitotic centromere associated kinesin (MCAK), is a member of the kinesin-like family of proteins. KIF2C is a cytoplasmic and nuclear protein, present throughout the cell cycle. KIF2C associates with the centromere early in prophase, and disassociates after telophase. KIF2C is abundant in thymus and testis, and present at lower levels in small intestine, the mucosal lining of the colon, and placenta. Human KIF2C maps to chromosome 1p34.1.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cytoplasm. Nucleus.
Gene Name
Positive Control
Human thymus or testis. Isoform 2 is testis-specific.
Immunogen
Recombinant fragment (around aa500-700) of human KIF2C protein (exact sequence is proprietary)
Alternate Names
Kinesin-like protein KIF2C, Kinesin-like protein 6, Mitotic centromere-associated kinesin, 4930402F02Rik; CT139; ESTM5; Kinesein Family Member 2C; kinesin like 6 (mitotic centromere associated kinesin); Kinesin like protein 6; Kinesin like protein KIF2C; KNSL6; MCAK; MGC11883; Mitotic centromere associated kinesin; OTTHUMP00000010066; X83316

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
KIF2C/4707
Chromosome Location
1p34.1
Mol. Weight of Antigen
75/81kDa

Functions

  • In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108).

Key References

  • Marder RJ et. al. Lab Invest 52: 497-504, 1985.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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