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Recombinant IL3RA / CD123 (Acute Myeloid Leukemia Marker) Antibody [IL3RA/2947R]

In Stock
Best Seller
HuProt Validated
Catalog Number Formulation Size Price
3563-RBM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3563-RBM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3563-RBM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Membrane
Gene Name
Positive Control
Lymph Node or Stomach., RPMI-8226 or HDLM-2 cells. Tonsil, THP-1
Immunogen
Recombinant fragment of human IL3RA protein (around aa 26-171) (exact sequence is proprietary)
Alternate Names
Interleukin-3 receptor subunit alpha, CD123; hIL3Ra; IL-3R-alpha; IL-3RA; IL3RAX; IL3RAY; IL3RX; IL3RY; Interleukin-3 Receptor, alpha; Interleukin3 receptor; Interleukin3 receptor, Y-chromosomal

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
IL3RA/2947R
Chromosome Location
Xp22.3 or Yp11.3
Mol. Weight of Antigen
70kDa

Functions

  • This is a receptor for interleukin-3.

Key References

  • Rollins-Raval M, et al. Appl Immunohistochem Mol Morphol. 2013 May;21(3):212-7.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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