Formalin-fixed, paraffin-embedded human Tongue stained with GLUT-1 Recombinant Rabbit Monoclonal Antibody (GLUT1/3132R).

SDS-PAGE Analysis Purified GLUT-1 Recombinant Rabbit Monoclonal Antibody (GLUT1/3132R). Confirmation of Purity and Integrity of Antibody.

Flow Cytometric Analysis of K562 cells using GLUT-1 Recombinant Rabbit Monoclonal Antibody (GLUT1/3132R) followed by goat anti-rabbit IgG-CF488 (Blue); Isotype Control (Red).

GLUT-1 (Tumor Progression and Mesothelioma Marker) [GLUT1/3132R]

Name: GLUT-1 (Tumor Progression and Mesothelioma Marker)
SKU: 6513-RBM6
Availability: InStock

Monoclonals Primary Antibodies Rabbit Monoclonals Recombinant Rabbit Monoclonals Recombinants

Summary

Recognizes a protein of 55kDa, which is identified as GLUT-1. Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. There are many types of glucose transport carrier proteins, designated as Glut-1 to Glut-12. Glut-1 is a major glucose transporter in the mammalian blood-brain barrier. It is expressed in high density on the membranes of human erythrocytes and the brain capillaries that comprise the blood-brain barrier. Glut-1 is expressed at variable levels in many human tissues. Overexpression of Glut-1 has been linked to tumor progression or poor survival of patients with carcinomas of the colon, breast, cervical, lung, bladder and mesothelioma. Glut-1 is a sensitive and specific marker for the differentiation of malignant mesothelioma (positive) from reactive mesothelium (negative).

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Product Properties & Targets

Host

Rabbit

Species Reactivity

Human

Isotype

IgG

Cellular Localization

Cell membrane, Melanosome, Photoreceptor inner segment

Gene Name

SLC2A1

Mol. Weight of Antigen

55kDa

Immunogen

Recombinant fragment of human GLUT1 protein (around aa 203-305) (exact sequence is proprietary)

Database Links

Entrez Gene ID

6513

Unigene

473721

SwissProt

P11166

Additional Information

Clone

GLUT1/3132R

Human Gene Symbol

SLC2A1

Chromosome Location

1p34.2

Known Applications & Suggested Dilutions

ELISA (For coating use Ab at 1-2ug/ml order Ab without BSA)
Flow Cytometry (1-2ug/million cells)
,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Key References

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.