Formalin-fixed, paraffin-embedded human Tonsil stained with FOXA1 Rabbit Recombinant Monoclonal Antibody (FOXA1/2230R).
SDS-PAGE Analysis Purified FOXA1 Rabbit Recombinant Monoclonal Antibody (FOXA1/2230R).
Western Blot Analysis of HeLa cell lysate using FOXA1 Rabbit Recombinant Monoclonal Antibody (FOXA1/2230R).
Flow Cytometric Analysis of PFA fixed MCF-7 cells using FOXA1 Rabbit Recombinant Monoclonal Antibody (FOXA1/2230R); followed by goat anti-rabbit IgG-CF488 (Blue); Goat anti-rabbit IgG-CF488 Is Control (Red).
Immunofluorescence Analysis of PFA-fixed MCF-7 cells labeled with FOXA1 Rabbit Recombinant Monoclonal Antibody (FOXA1/2230R); followed by goat anti- rabbit IgG- CF488. Phalloiden stains the membrane(Red).
The transcription factor Forkhead-box A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors.HNF-1 (), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. FOXA1 expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.
