CETN1 / Centrin-1 Antibody [CETN1/9878]

Summary

Centrin-1 Antibody (2A6) is an IgG₁ κ mouse monoclonal Centrin-1 antibody (also designated Caltractin isoform 2 antibody or CETN1 antibody) that detects the Centrin-1 protein of human origin by WB, IP and ELISA. Centrin-1 Antibody (2A6) is available as the non-conjugated anti-Centrin-1 antibody. EF-hand type Ca2+-binding proteins consists of several family members, including Centrin-1, Centrin-2 and Centrin-3. The Centrin proteins are ubiquitously expressed cytoskeletal components that show increased expression during cell differentiation. Tissues where cilia are present, such as the retina and testis, express both Centrin-1 and -2, but Centrin-2 is also expressed in nondifferentiated, nonciliated retinal cells (retinoblastoma cells), liver, skeletal muscle, and cardiac muscle. In these tissues, Centrin associates with the centrosomes, mitotic spindle poles, and basal bodies. Knockdown studies reveal a requirement for Centrin in centriole duplication and organization of spindle pole morphology and the completion of cytokinesis. Centrin-3 plays a role in centrosome reproduction.