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CETN1 / Centrin-1 Antibody [CETN1/9877]

In Stock
Catalog Number Formulation Size Price
1068-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1068-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1068-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

Centrin-1 Antibody (2A6) is an IgG1 κ mouse monoclonal Centrin-1 antibody (also designated Caltractin isoform 2 antibody or CETN1 antibody) that detects the Centrin-1 protein of human origin by WB, IP and ELISA. Centrin-1 Antibody (2A6) is available as the non-conjugated anti-Centrin-1 antibody. EF-hand type Ca2+-binding proteins consists of several family members, including Centrin-1, Centrin-2 and Centrin-3. The Centrin proteins are ubiquitously expressed cytoskeletal components that show increased expression during cell differentiation. Tissues where cilia are present, such as the retina and testis, express both Centrin-1 and -2, but Centrin-2 is also expressed in nondifferentiated, nonciliated retinal cells (retinoblastoma cells), liver, skeletal muscle, and cardiac muscle. In these tissues, Centrin associates with the centrosomes, mitotic spindle poles, and basal bodies. Knockdown studies reveal a requirement for Centrin in centriole duplication and organization of spindle pole morphology and the completion of cytokinesis. Centrin-3 plays a role in centrosome reproduction.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG /
Cellular Localization
Cell projection, Centrosome, Cytoplasm, Cytoskeleton
Gene Name
Positive Control
Human testis.
Immunogen
Recombinant fragment (around aa1-172) of human CETN1 protein (exact sequence is proprietary)
Alternate Names
Centrin-1, Caltractin antibody Caltractin isoform 2 antibody; CEN 1 antibody; CEN1 antibody; Centrin EF hand protein 1 antibody; Centrin-1 antibody; Centrin1 antibody; CETN 1 antibody; CETN antibody; CETN1 antibody; CETN1_HUMAN antibody; EF hand protein 1 antibody, CEN1; CETN

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CETN1/9877
Chromosome Location
18p11.32
Mol. Weight of Antigen
20KDa

Functions

  • Plays a fundamental role in microtubule-organizing center structure and function.

Key References

  • Fu-Jun, L., et al. 2012. Oncol. Lett. 4: 1097-1103.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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