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CDw17 (Lactosylceramide or LacCer) Antibody [HuLy-m13]

In Stock
Catalog Number Formulation Size Price
MSM1-1088-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MSM1-1088-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MSM1-1088-P1BX
Purified Ab WITHOUT BSA at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

CD17 is an intermediate glycosphingolipid from the metabolism of higher gangliosides that localizes to sphingolipid-sterol rafts. CD17 is detectable in monocytes, granulocytes, basophils, platelets, a subset of peripheral B cells (CD19+) and tonsil dendritic cells. It is rapidly down regulated on activated granulocytes and is upregulated on IL-2 activated T lymphocytes. CD17 binds to bacteria and may function in phagocytosis. VEGF-treated endothelial cells can produce CD17, which can then mediate signaling toward PECAM-1 expression and angiogenesis. Tumor necrosis factor )-induced astrogliosis (astrocyte proliferation and glial fibrillary acidic protein (GFAP) upregulation) in response to neuro-inflammation (i.e. spinal cord injury) causes an increase in intracellular levels of CD17. Aberrant levels of glycosphingolipids are a feature of cancer cells and may influence integrin clustering and internalization.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgM / Kappa
Cellular Localization
N/A
Gene Name
N/A
Positive Control
Human PBL. Tonsil.
Immunogen
β-2 Microglobulin associated proteins from a detergent lysate of human PBL
Alternate Names
N/A, N/A, Lactosylceramide; LacCer; β-D-galactosyl-(1-4)-β-D-glucosyl-(1-1')-ceramide;CDw17

Database Links

Entrez Gene ID
SwissProt
N/A

Additional Information

Clone
HuLy-m13
Chromosome Location
Not known
Mol. Weight of Antigen
Not Known

Functions

  • N/A

Key References

  • Lovering, K.E. Characterisation of the Tcell surface by monoclonal antibodies. PhD thesis, University of Melbourne, 1985.
  • Knapp W. Leukocyte Typing IV, Oxford Univ. Press, pp. 810811, 1989. Also data on M119, pp 861, 874, 877 879, 897, 907, 923, 925.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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