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CD134, Mouse (OX40) Antibody [OX-86]

In Stock
Catalog Number Formulation Size Price
RTM1-2004-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
RTM1-2004-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
RTM1-2004-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4+and CD8+T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4+ T cell responses in vivo and in vitro. CD134 is expressed on activated CD4+ T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells.

Product Properties & Targets

Antibody Type
Host
Rat
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Membrane
Gene Name
Positive Control
MPBMC's. Spleen, Thymus or Lymph Node.
Immunogen
Purified recombinant Mouse OX-40 antigen
Alternate Names
Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, CD134; IMD16; Lymphoid activation antigen (ACT35); OX40 cell surface antigen; OX40L receptor; TAX transcriptionally activated glycoprotein 1 receptor; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4); Txgp1l

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
OX-86
Chromosome Location
4 E2; 4 87.68 cM (Mouse)
Mol. Weight of Antigen
~50kDa

Functions

  • Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).

Key References

  • Higgins LM, et al. 1999. J. Immunol. 162:486. (Flow IHC)
  • del Rio ML, et al. 2011. Transpl. Int. 24:501. (Flow)
  • Al-Shamkhani A, et al. 1996. Eur. J. Immunol. 26:1695. (Agonist)

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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