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CD134, Mouse (OX40) Antibody [OX-86]

Additional information

Catalog Number: RTM1-2004
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
RTM1-2004-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
RTM1-2004-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
RTM1-2004-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD134, Mouse (OX40) Antibody

SDS-PAGE Analysis of Purified CD134 Rat Monoclonal Antibody (OX-86). Confirmation of Integrity and Purity of Antibody.

  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Rat Monoclonals
Host
Rat
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Mouse
Clone
OX-86
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Membrane
Gene Name
TNFRSF4
Positive Control
MPBMC's. Spleen, Thymus or Lymph Node.
Immunogen
Purified recombinant Mouse OX-40 antigen
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity (By similarity).
Key References
  • Higgins LM, et al. 1999. J. Immunol. 162:486. (Flow IHC)
  • del Rio ML, et al. 2011. Transpl. Int. 24:501. (Flow)
  • Al-Shamkhani A, et al. 1996. Eur. J. Immunol. 26:1695. (Agonist)
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
22163
SwissProt
P47741
Chromosome Location
4 E2; 4 87.68 cM (Mouse)
Mol. Weight of Antigen
~50kDa
Alternate Names
Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, CD134; IMD16; Lymphoid activation antigen (ACT35); OX40 cell surface antigen; OX40L receptor; TAX transcriptionally activated glycoprotein 1 receptor; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4); Txgp1l

Summary

CD134 is a type I integral membrane protein. This receptor is expressed on activated CD4+and CD8+T cells and B cells. The CD134 binds to CD134 ligand (CD252) to provide a costimulatory signal that is independent of CD28. CD134 is involved in coordinating CD4 T cell selection, migration and cytokine differentiation in T helper (Th)1 and Th2 cells. CD134 is also involved in the stimulation of T cells, T dependent humoral response and generation of optimal CD4+ T cell responses in vivo and in vitro. CD134 is expressed on activated CD4+ T lymphocytes, and its ligand, CD134L, is found preferentially on activated B cells. Engagement of CD134 with its ligand, CD134L, delivers a strong costimulatory signal to effector T cells.

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