OX40 / CD134 / TNFRSF4 (Immuno-Oncology Target) Antibody [OX40/3428]

These antibodies are validated on HuProtâ„¢ Human Protein Microarrays containing over 21,000 full-length human proteins, including the specific target of interest. LEARN MORE

Additional information

Catalog Number: 7293-MSM8
Reactivity:

,

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

In Stock
Catalog Number Formulation Size Price
7293-MSM8-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7293-MSM8-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7293-MSM8-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
  • ELISA

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Product Properties

Antibody Type
Host
Mouse
Applications
Species Reactivity
Clone
OX40/3428
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Membrane
Gene Name
Positive Control
HuT78 cells or human peripheral blood leukocytes (hPBL)., MOLT4
Immunogen
Recombinant fragment of human OX40 (CD134) protein (around aa 59-205) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

Related Antibodies

Other Information

Functions
Key References
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
SwissProt
Chromosome Location
1p36.33
Mol. Weight of Antigen
43kDa
Alternate Names
Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, ACT35; CD134; Lymphoid activation antigen ACT35; OX40; TAX transcriptionally-activated glycoprotein 1 receptor; TNFRSF4 (Tumor necrosis factor receptor superfamily member 4)

Summary

This MAb recognizes a protein of 43kDa, identified as OX40, which is also known as CD134. OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand / TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells. OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.

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