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OX40 / CD134 / TNFRSF4 (Immuno-Oncology Target) Antibody [OX40/3427]

In Stock
Catalog Number Formulation Size Price
7293-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
7293-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
7293-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

This MAb recognizes a protein of 43kDa, identified as OX40, which is also known as CD134. OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand / TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells. OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2c / Kappa
Cellular Localization
Membrane
Gene Name
Positive Control
HuT78 cells or human peripheral blood leukocytes (hPBL)., MOLT4
Immunogen
Recombinant fragment of human OX40 (CD134) protein (around aa 59-205) (exact sequence is proprietary)
Alternate Names
Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, ACT35; CD134; Lymphoid activation antigen ACT35; OX40; TAX transcriptionally-activated glycoprotein 1 receptor; TNFRSF4 (Tumor necrosis factor receptor superfamily member 4)

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
OX40/3427
Chromosome Location
1p36.33
Mol. Weight of Antigen
43kDa

Functions

  • Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
  • (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

Key References

  • Durkop H, et al. 1995. Brit. J. Haematol. 91:927.
  • Durkop H, et al. 1997. Brit. J. Haematol. 98:863.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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