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Recombinant Aciculin / Phosphoglucomutase 5 (PGM5) Antibody [rPGM5/7164]

In Stock
Catalog Number Formulation Size Price
5239-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
5239-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
5239-MSM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunofluorescence (IF)
1-3ug/ml
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

Aciculin, also known as PGM5 (phosphoglucomutase 5) or PGMRP, is a 567 amino acid protein that belongs to the phosphoglucomutase family of phosphotransferases, which play an important role in the interconversion of glucose-1-phosphate and glucose-6-phosphate. Localized to the cell junction and expressed at high levels in smooth and cardiac muscle, Aciculin binds magnesium as a cofactor and interacts with dystrophin and utrophin, possibly playing a role in cytoskeletal organization and function. Aciculin exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.

Product Properties & Targets

Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Adherens junction, Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Sarcolemma
Gene Name
Positive Control
Human heart muscle or smooth muscle (IHC). Mouse heart tissue lysate (WB).
Immunogen
Recombinant full-length human PGM5 protein
Alternate Names
Phosphoglucomutase-like protein 5, Aciculin, Phosphoglucomutase-related protein, Aciculin; PGM-RP; PGM5; PGMRP; phosphoglucomutase 5; Phosphoglucomutase-like protein 5; Phosphoglucomutase-related protein

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
rPGM5/7164
Chromosome Location
9q21.11
Mol. Weight of Antigen
56kDa

Functions

  • Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905).

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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