Aciculin / Phosphoglucomutase 5 (PGM5) [PGM5/3552]



Aciculin, also known as PGM5 (phosphoglucomutase 5) or PGMRP, is a 567 amino acid protein that belongs to the phosphoglucomutase family of phosphotransferases, which play an important role in the interconversion of glucose-1-phosphate and glucose-6-phosphate. Localized to the cell junction and expressed at high levels in smooth and cardiac muscle, Aciculin binds magnesium as a cofactor and interacts with dystrophin and utrophin, possibly playing a role in cytoskeletal organization and function. Aciculin exists as two alternatively spliced isoforms and is encoded by a gene that maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome.

Product Properties & Targets

Species Reactivity
Cellular Localization
Adherens junction, Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Sarcolemma
Light Chain
Gene Name
Positive Control
Human heart muscle or smooth muscle (IHC).Mouse heart tissue lysate (WB).
Recombinant full-length human PGM5 protein
Alternate Names
Phosphoglucomutase-like protein 5, Aciculin, Phosphoglucomutase-related protein, Aciculin; PGM-RP; PGM5; PGMRP; phosphoglucomutase 5; Phosphoglucomutase-like protein 5; Phosphoglucomutase-related protein

Database Links

Entrez Gene ID

Additional Information

Human Gene Symbol
Chromosome Location
Mol. Weight of Antigen


  • Component of adherens-type cell-cell and cell-matrix junctions (PubMed:8175905). Has no phosphoglucomutase activity in vitro (PubMed:8175905).

Known Applications & Suggested Dilutions

  • ELISA (For coating, order antibody without BSA)
  • Immunofluorescence (1-2ug/ml)
  • Western Blot (1-2ug/ml)
  • Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 &degC followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Key References

  • Belkin, A.M. and Burridge, K. 1994. Expression and localization of the phosphoglucomutase-related cytoskeletal protein, Aciculin, in skeletal muscle. J. Cell Sci. 107: 1993-2003.

Storage & Stability

Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


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