Learn about our comprehensive antibody validation methods to ensure monospecificity.  Antibody Validation>>

CTLA-4 Antibodies

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) has a molecular weight of approximately 33-34 kDa and is primarily expressed on activated T-cells, specifically CD4+ and CD8+ T-cells. It is a crucial immune checkpoint receptor that negatively regulates T-cell activation. It competes with the co-stimulatory molecule CD28 for binding to the ligands B7-1 (CD80) and B7-2 (CD86) on antigen-presenting cells (APCs), which inhibits T-cell activation and helps maintain immune homeostasis.

CTLA-4 is associated with autoimmune diseases, as its dysregulation can lead to an overactive immune response against self-antigens. Additionally, mutations in Cytotoxic T-Lymphocyte-Associated Protein 4 are linked to certain autoimmune disorders, such as systemic lupus erythematosus (SLE) and autoimmune thyroid diseases. Furthermore, it is a target in cancer immunotherapy due to its role in immune evasion by tumor cells.

Therapeutically, antibodies against CTLA-4 have been shown to block the CTLA-4 inhibitory function, promoting T-cell activation and enhancing the immune response against cancer cells, particularly in treating advanced melanoma. In diagnostics, assessing CTLA-4 expression or genetic variations may help predict responses to immunotherapy and guide treatment decisions.

Synonyms

Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, ALPS5; CD152; Celiac disease 3 (CELIAC3); Cytotoxic T-lymphocyte-associated antigen 4 (CTLA4); GRD4; GSE; ICOS; Insulin-dependent Diabetes Mellitus 12 (IDDM12)

Research Areas

Cardiovascular, Immunology, CTLA-4 blockade immunotherapy, Transcription Factors

Showing all 5 results

CTLA-4

Showing all 5 results

PARTNERSHIP OPPORTUNITIES

We hold Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.

LETS TALK