Androgen Receptor (AR) belongs to the nuclear receptor superfamily and has a molecular weight of approximately 110 kDa. This protein is expressed intracellularly, primarily in the cytoplasm. Upon binding with androgens, it translocates into the nucleus, acting as a transcription factor and modulating gene expression. Posttranslational modifications such as phosphorylation, acetylation, and ubiquitination have been reported to regulate AR, influencing its stability and transcriptional activity.
AR’s fundamental role lies in mediating the effects of androgens, including testosterone and dihydrotestosterone. This receptor plays a crucial role in developing and maintaining male reproductive tissues and secondary sexual characteristics. Beyond reproduction, AR is expressed in various cells, organs, and tissues, including the prostate, skeletal muscle, and adipose tissue.
The expression of AR is subject to modulation by factors such as age, hormonal fluctuations, and pathological conditions. Dysregulation of AR signaling is implicated in numerous health issues, with a prominent role in prostate cancer, leading to uncontrolled cell growth. Other conditions associated with AR include androgen insensitivity syndrome (AIS) and some types of hair loss.
Antibodies against AR are used in research and diagnostic applications. They can be employed to study the expression, localization, and activity of the AR in tissues and cells. In cancer research, these antibodies may be used to assess the AR status in tumor tissues through immunohistochemistry (IHC), providing valuable information for prognosis and treatment decisions. Additionally, targeting the AR with therapeutic antibodies or small molecules is an active area of research for developing anticancer drugs.
The implications of AR in human health and disease underscore the significance of targeted research and diagnostic tools. At Neobiotechnologies, we are committed to providing high-quality antibodies for the scientific community. Explore our comprehensive catalog to access reliable tools for studying and targeting AR, and join us in pursuing knowledge and improved healthcare outcomes.
Synonyms
Androgen receptor, Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AIS; Dihydrotestosterone receptor (DHTR); HUMARA; HYSP1; Kennedy disease (KD); Nuclear receptor subfamily 3 group C member 4 (NR3C4); SMAX1; Spinal and bulbar muscular atrophy (SBMA); Testicular Feminization (TFM)
Research Areas
AKT Signaling, Signal Transduction, Transcription Factors
