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STAT2

Mouse Monoclonal Antibody [Clone STAT2/2650]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

199.00

459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00

459.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with STAT2 Mouse Monoclonal Antibody (STAT2/2650).

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with STAT2 Mouse Monoclonal Antibody (STAT2/2650).

SDS-PAGE Analysis Purified STAT2 Mouse Monoclonal Antibody (STAT2/2650). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with STAT2 Mouse Monoclonal Antibody (STAT2/2650).

SDS-PAGE Analysis Purified STAT2 Mouse Monoclonal Antibody (STAT2/2650). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator (ISGF3); P113; signal transducer and activator of transcription 2 113kD (STAT113); Signal transducer and activator of transcription 2 (STAT2)

Positive Control

Ramos and Jurkat cell lysates. HeLa cell extract. Human lung carcinoma tissue.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human STAT2 protein

Cellular Localization

Cell surface.

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

113kDa

Specificity & Comments

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN- is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.