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STAT2 Antibody [STAT2/2650]

In Stock
Catalog Number Formulation Size Price
6773-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
6773-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
6773-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
STAT2 Antibody

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with STAT2 Mouse Monoclonal Antibody (STAT2/2650).

STAT2 Antibody - Image 2

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with STAT2 Mouse Monoclonal Antibody (STAT2/2650).

STAT2 Antibody - Image 3

SDS-PAGE Analysis of Purified STAT2 Mouse Monoclonal Antibody (STAT2/2650). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN- is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, Cytokine Signaling, Infectious Disease
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
STAT2
Positive Control
Ramos and Jurkat cell lysates. HeLa cell extract. Human lung carcinoma tissue.
Immunogen
Recombinant full-length human STAT2 protein
Alternate Names
Signal transducer and activator of transcription 2, p113, Homo sapiens interferon alpha induced transcriptional activator; interferon alpha induced transcriptional activator (ISGF3); P113; signal transducer and activator of transcription 2 113kD (STAT113); Signal transducer and activator of transcription 2 (STAT2)

Database Links

Entrez Gene ID
6773
SwissProt
P52630

Additional Information

Clone
STAT2/2650
Chromosome Location
12q13.3
Mol. Weight of Antigen
113kDa

Related Antibodies

View All STAT2 Antibodies

Functions

  • Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state (PubMed:9020188, PubMed:23391734). In addition, has also a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs (PubMed:28165510). Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively (PubMed:26122121, PubMed:23391734, PubMed:9020188).

Key References

  • Zhong, Z., et al. 1994. Science 264: 95-98.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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