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Home >> Antibodies >> Ornithine Decarboxylase-1 (ODC-1)

Ornithine Decarboxylase-1 (ODC-1)

Recombinant Rabbit Monoclonal Antibody [Clone ODC1/3636R]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified ODC-1 Recombinant Rabbit Monoclonal Antibody (ODC1/3636R). Confirmation of Purity and Integrity of Antibody.

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Formalin-fixed, paraffin-embedded human prostate carcinoma stained with ODC-1 Recombinant Rabbit Monoclonal Antibody (ODC1/3636R).

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Western Blot Analysis of PC3 cell lysate using ODC-1 Recombinant Rabbit Monoclonal Antibody (ODC1/3636R).

Product Details

Synonyms

Ornithine decarboxylase structural 1; RNODC

Positive Control

Human placenta or prostate carcinoma tissue (IHC).

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human ODC-1 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Mouse. Rat.

Host / Ig Isotype

Rabbit / IgG

Mol. Weight of Antigen

53kDa

Specificity & Comments

Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Schipper RG; et al. Journal of Immunological Methods, 1993, 161(2):205-15.

Bioinformatics

  •  Entrez Gene ID: 4953
  •  Gene Symbol: ODC1
  •  SwissProt: P11926
  •  Chromosome Location: 2p25.1
  •  Unigene: 467701
NBT03636