Formalin-fixed, paraffin-embedded human lung adenocarcinoma stained with Napsin A Recombinant Mouse Monoclonal Antibody (rNAPSA/6926). Inset: PBS instead of primary antibody, secondary negative control.
SDS-PAGE Analysis Purified Napsin A Recombinant Mouse Monoclonal Antibody (rNAPSA/6926). Confirmation of Integrity and Purity of Antibody.
Formalin-fixed, paraffin-embedded human kidney stained with Napsin A Recombinant Mouse Monoclonal Antibody (rNAPSA/6926). HIER: Tris/EDTA, pH9.0, 45min. 2°: HRP-polymer, 30min. DAB, 5min.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Napsin is a pepsin-like aspartic proteinase connected with maturation of surfactant protein B. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.