Formalin-fixed, paraffin-embedded human colonstained with MSH2Recombinant Rabbit Monoclonal Antibody (MSH2/6549R).
Formalin-fixed, paraffin-embedded human colon stained with MSH2Recombinant Rabbit Monoclonal Antibody (MSH2/6549R).
Western blot analysis of HCT116 cell lysate using MSH2Recombinant Rabbit Monoclonal Antibody (MSH2/6549R).
SDS-PAGE Analysis Purified MSH2Recombinant Rabbit Monoclonal Antibody (MSH2/6549R). Confirmation of Purity and Integrity of Antibody.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.