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Home >> Antibodies >> Cytokeratin 15 (Esophageal Squamous Cell Carcinoma Marker)

Cytokeratin 15 (Esophageal Squamous Cell Carcinoma Marker)

Mouse Monoclonal Antibody [Clone LHK15]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
img

Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin 15 Mouse Monoclonal Antibody (LHK15).

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SDS-PAGE Analysis Purified Cytokeratin 15 Mouse Monoclonal Antibody (LHK15). Confirmation of Integrity and Purity of Antibody

Product Details

Synonyms

CK15; Cytokeratin 15; K1CO; Ka15; Keratin 15 basic; Keratin 15 beta; Keratin complex 1 acidic gene 15; Keratin type I cytoskeletal 15; KRT15; KRTB; KRTL15; Type I cytoskeletal 15; Type I keratin Ka15

Positive Control

A431 cells. Skin or Colon.

Known Applications & Suggested Dilutions

IHC-P         More Details

Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

A 17 amino acids synthetic peptide from the C- terminal of Human Cytokeratin 15

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Rat. Cow.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

52kDa

Specificity & Comments

Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Yu-Hong Shen, Cui-Ping Xu, Zhi-Meng Shi, Yan-Jiao Zhang, Ya-Guang Qiao, He-Ping Zhao. Cytokeratin 15 is an Effective Indicator for Progression and Malignancy of Esophageal Squamous Cell Carcinomas. Asian Pac J Cancer Prev, 17 (9), 4217-4222.

Bioinformatics

  •  Entrez Gene ID: 3866
  •  Gene Symbol: KRT15
  •  SwissProt: P19012
  •  Chromosome Location: 17q21.2
  •  Unigene: 654570
NBT01651