Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin 15 Rabbit Recombinant Monoclonal Ab (KRT15/2103R).
Formalin-fixed, paraffin-embedded human Prostate stained with Cytokeratin 15 Rabbit Recombinant Monoclonal Ab (KRT15/2103R).
SDS-PAGE Analysis Purified Cytokeratin 15 Rabbit Recombinant Monoclonal Ab (KRT15/2103R). Confirmation of Purity and Integrity of Antibody.
Flow Cytometric Analysis of HeLa cells using KRT15 Rabbit Recombinant Monoclonal Ab (KRT15/2103R) followed by Goat anti-rabbit IgG-CF488 (Blue); Isotype Control (Red).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. KRT15 is downregulated in activated keratinocytes. It is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.