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Home >> Antibodies >> Cyclin E (G1/S-Phase Cyclin)

Cyclin E (G1/S-Phase Cyclin)

Mouse Monoclonal Antibody [Clone CCNE1/2587]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified Cyclin E Mouse Monoclonal Antibody (CCNE1/2587). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

CCNE1; Cyclin E1; G1/S-specific cyclin-E1

Positive Control

HeLa cells. Breast or Colon Carcinoma.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant human Cyclin E (CCNE1) protein fragment (around aa 10-176) (exact sequence is proprietary)

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG, kappa

Mol. Weight of Antigen

53kDa

Specificity & Comments

Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Camacho F I, Garcia J F, Sanchez-Verde L, et al. American Journal of Pathology. 158 (4): 1363-1369 (2001).

Bioinformatics

  •  Entrez Gene ID: 898
  •  Gene Symbol: CCNE1
  •  SwissProt: P24864
  •  Chromosome Location: 19q12
  •  Unigene: 244723
NBT02587