SDS-PAGE Analysis Purified Cyclin A2 Mouse Monoclonal Antibody (E67). Confirmation of Integrity and Purity of Antibody.
Formalin-fixed, paraffin-embedded human Endometrium stained with Cyclin A2 Mouse Monoclonal Antibody (E67).
Western Blot Analysis of HeLa cell lysate using Cyclin A2 Mouse Monoclonal Antibody (E67).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It recognizes a protein of 54kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase.