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Home >> Antibodies >> CD6 (Negative Marker of T-regulatory Cells)

CD6 (Negative Marker of T-regulatory Cells)

Mouse Monoclonal Antibody [Clone SPV-L14]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified CD6 Mouse Monoclonal Antibody (SPV-L14).

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Flow Cytometric Analysis of MOLT-4 cells. CD6 Mouse Monoclonal Antibody (SPV-L14) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).

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Immunofluorescence staining of MOLT4 cells using CD6 Mouse Monoclonal Antibody (SPV-L14) followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei are stained with Reddot.

Product Details

Synonyms

T12; TP120

Positive Control

CCRF-CEM, Jurkat cells, Tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/ml)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

CD8+ cytotoxic T-cell clone

Cellular Localization

Cell surface and cytoplasmic

Species Reactivity

Human. Mouse.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

90-130kDa

Specificity & Comments

CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Kamoun et al., J. Immunol. 127, 987, 1981
  2. Reinherz et al., Proc. Nat. Acad. Sci. 79, 6047, 1982
  3. Yssel, H., de Vries, J.E., Borst, J. and Spits, H. Distribution and functional analysis of a 120-130 kDa T cell surface antigen. Cell. Immunol. 105: 161-173, 1987.
  4. Bazil, V et. al. 1989. Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102. Folia. Biol. 35:289-297.

Bioinformatics

  •  Entrez Gene ID: 923
  •  Gene Symbol: CD6
  •  SwissProt: P30203
  •  Chromosome Location: 11q12.2
  •  Unigene: 744366
NBT00402