SDS-PAGE Analysis Purified CD6 Mouse Monoclonal Antibody (SPV-L14).
Flow Cytometric Analysis of MOLT-4 cells. CD6 Mouse Monoclonal Antibody (SPV-L14) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).
Immunofluorescence staining of MOLT4 cells using CD6 Mouse Monoclonal Antibody (SPV-L14) followed by goat anti-Mouse IgG conjugated to CF488 (green). Nuclei are stained with Reddot.
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.