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Home >> Antibodies >> CD46 (Membrane Cofactor Protein)

CD46 (Membrane Cofactor Protein)

Mouse Monoclonal Antibody [Clone 169-1-E4.3]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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SDS-PAGE Analysis Purified CD46 Mouse Monoclonal Antibody (169-1-E4.3). Confirmation of Integrity and Purity of Antibody

Product Details

Synonyms

AHUS2; Complement membrane cofactor protein; MCP; Measles virus receptor; Membrane cofactor protein; MIC10; TLX; Trophoblast leucocyte common antigen; Trophoblast lymphocyte cross reactive antigen

Positive Control

K562, U937, HL60, HeLa and Jurkat cells and human lymphocytes. Lymph node and tonsil.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Stimulated human leukocytes

Cellular Localization

Cell Surface

Species Reactivity

Human. Baboon. Does not react with Horse.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

52-58kDa

Specificity & Comments

Recognizes a protein of 52kDa-58kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Sparrow et al. Human Immunol 7, 115 (1983).
  2. Purcell et al. Immunol Cell Biol 67, 279289 (1989).

Bioinformatics

  •  Entrez Gene ID: 4179
  •  Gene Symbol: CD46
  •  SwissProt: P15529
  •  Chromosome Location: 1q32
  •  Unigene: 510402
NBT00930