Formalin-fixed, paraffin-embedded human tonsil stained with CD3e Recombinant Mouse Monoclonal Antibody (rC3e/1931) at 2ug/ml. Inset: PBS instead of primary antibody, secondary control.
SDS-PAGE Analysis Purified CD3e Recombinant Mouse Monoclonal Antibody (rC3e/1931). Confirmation of Purity and Integrity of Antibody.
Analysis of Protein Array containing more than 19,000 full-length human proteins using CD3e Monospecific Recombinant Mouse Monoclonal Antibody (rC3e/1931).
Known Applications & Suggested Dilutions
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes the epsilon-chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the T cell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface. CD3 antigen is a highly specific marker for T cells, and is present in majority of T cell neoplasms.