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Home >> Antibodies >> CD19 (B-Lymphocyte Marker)

CD19 (B-Lymphocyte Marker)

Mouse Monoclonal Antibody [Clone CVID3/429]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
459.00
459.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
459.00
459.00
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Flow Cytometric Analysis of Raji cells. CD19 Mouse Monoclonal Antibody (CVID3/429) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

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Immunofluorescent staining of Raji cells. CD19 Mouse Monoclonal Antibody (CVID3/429) followed by goat anti-Mouse IgG-CF488 (Green). The nuclear counterstain is Reddot (Red)

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SDS-PAGE Analysis Purified CD19 Mouse Monoclonal Antibody (CVID3/429). Confirmation of Purity and Integrity of Antibody.

Product Details

Synonyms

B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CVID3; Leu-12; Lymphocyte Surface Antigen; T-cell surface antigen Leu-12

Positive Control

Raji cells, Tonsil, Lymph Node or Spleen.

Known Applications & Suggested Dilutions

Flow Cyt, IF         More Details

Flow Cytometry (1-2ug/million cells)
Immunofluorescence (1-2ug/ml)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human CD19 protein

Cellular Localization

Cell Surface

Species Reactivity

Human. Chimpanzee. Monkey.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

95kDa

Specificity & Comments

CD19 is a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains. CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bregni, M. Siena, S., Formosa, A., Lappi, D.A., Martineau, D., Malavasi, F., Dorken, B., Bonadonna, G. and Gianni, A.M. 1989. B cell restricted saporin immunotoxins: activity against B cell lines and chronic lymphocytic leukemia cells. Blood 73: 753-762

Bioinformatics

  •  Entrez Gene ID: 930
  •  Gene Symbol: CD19
  •  SwissProt: P15391
  •  Chromosome Location: 16p11.2
  •  Unigene: 652262
NBT00429