
Flow Cytometric Analysis of PFA-fixed HeLa cells. ZNF488 Mouse Monoclonal Antibody (PCRP-ZNF488-2D8) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).

SDS-PAGE Analysis of Purified ZNF488 Mouse Monoclonal Antibody (PCRP-ZNF488-2D8). Confirmation of Purity and Integrity of Antibody.

Formalin-fixed, paraffin-embedded human uterus stained with ZNF488 Mouse Monoclonal Antibody (PCRP-ZNF488-2D8). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Analysis of Protein Array containing more than 19,000 full-length human proteins using ZNF488 Mouse Monoclonal (PCRP-ZNF488-2D8). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc finger proteins contain a Kruppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF488 is a 340 amino acid transcriptional regulator belonging to the Kruppel C2H2-type zinc finger protein family. ZNF488 localizes to the nucleus and contains two C2H2-type zinc fingers. ZNF488 is encoded by a gene located on chromosome 10, which contains a plethora of interesting genes and represents between 4 and 4.5 percent of the total DNA in cells. Jackson-Weiss, Cowden and Usher syndromes are a few diseases related to genes on chromosome 10.
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