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TACSTD2 / TROP2 (Epithelial Marker) Antibody [TACSTD2/2151]

In Stock
Catalog Number Formulation Size Price
4070-MSM1-B1
Purified Ab conjugated to Biotin
0.5ml at 100ug/ml
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

TACSTD2 is a cell surface glycoprotein receptor. It is a single pass type I membrane protein containing one thyroglobulin type-1 domain, an epidermal growth factor-like repeat, a phosphatidylinositol binding site and tyrosine phosphorylation sites near the C-terminus. It plays a role in transducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multi-stratified epithelia. It is also highly expressed in several types of tumors and is involved in regulating the growth of carcinoma cells.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b /
Cellular Localization
Cell surface, Membrane
Gene Name
Positive Control
HT29 cells. Human breast or colon carcinoma.
Immunogen
Recombinant fragment of human TACSTD2 protein (around aa 31-274) (exact sequence is proprietary)
Alternate Names
Tumor-associated calcium signal transducer 2, Cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1, Pancreatic carcinoma marker protein GA733-1, Cell surface glycoprotein Trop-2; Membrane Component Chromosome 1, Surface Marker 1 (M1S1); Pancreatic Carcinoma Marker Protein GA733-1; TROP2; Tumor-Associated Calcium Signal Transducer 2 (TACSTD2)

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
TACSTD2/2151
Chromosome Location
1p32.1
Mol. Weight of Antigen
40kDa

Functions

  • May function as a growth factor receptor.

Key References

  • Fornaro, M., et al. 1995. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int. J. Cancer 62: 610-618.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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