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Recombinant Synaptic Vesicle Protein 2 (SV2) (Marker of Neuroendocrine Cells) Antibody [r15E11]

In Stock
Catalog Number Formulation Size Price
9900-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
9900-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
9900-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day
Synaptic Vesicle Protein 2 Antibody in Immunohistochemistry (IHC (P))

Synaptic Vesicle Protein 2 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human testis stained with Synaptic Vesicle Protein 2 (SV2) Recombinant Mouse Monoclonal Antibody (r15E11). Inset: PBS instead of primary antibody; secondary only negative control.

Synaptic Vesicle Protein 2 Antibody in SDS-PAGE

Synaptic Vesicle Protein 2 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Synaptic Vesicle Protein 2 (SV2) Recombinant Mouse Monoclonal Antibody (r15E11). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Synaptic vesicle protein 2 (SV2) is an integral membrane glycoprotein. It is required for normal neurotransmission and may play a role in the regulation of calcium-stimulated exocytosis. SV2 exists in three forms, SV2A, SV2B and SV2C, each containing 12 transmembrane spanning regions. SV2 proteins are among the most abundant and conserved components of synaptic vesicles in vertebrates. They are present on all small synaptic vesicles independent of transmitter type. SV2A and SV2B are widely distributed in the nervous system, whereas SV2C is only observed in a small number of neurons in a few areas of the brain. SV2A is expressed at the highest levels in subcortical regions, whereas the highest level of expression of SV2B is in the cortex and hippocampus. SV2 is expressed on secretory vesicles of neuroendocrine cells in the GI tract, pancreas, anterior pituitary gland, thyroid, parathyroid and adrenal medulla and also in exocrine chief cells of gastric mucosa.

Product Properties & Targets

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Neuroscience
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm
Gene Name
SV2A
Positive Control
Human brain.
Immunogen
Prokaryotic recombinant protein corresponding to the N-terminal cytoplasmic domain of the human synaptic vesicle 2A molecule which shares some regions of homology with the SV2B molecule
Alternate Names
Synaptic vesicle glycoprotein 2A, SV2A, KIAA0736, PSEC0174, KIAA0736 | PSEC0174 | SV2A | Synaptic vesicle glycoprotein 2A

Database Links

Entrez Gene ID
9900
SwissProt
Q7L0J3

Additional Information

Clone
r15E11
Chromosome Location
1q21.2
Mol. Weight of Antigen
93kDa

Related Antibodies

View All SV2A Antibodies

Functions

  • Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.

Key References

  • Jakobsen A-M, Ahlman H, Wängberg B, et al. Journal of Pathology. 196: 44–50 (2002).
  • Portela-Gomes G M, Lukinius A and Grimelius L. American Journal of Pathology. 157 (4): 1299–1309 (2000).
  • Janz R and Südhof T C. Neuroscience. 94 (4): 1279–1290 (1999).
  • Bajjalieh S M, Peterson K, Linial M, et al. Proceedings of the National Academy of Sciences USA. 90: 2150–2154 (1993).
  • Bajjalieh S M, Peterson K, Shinghal R, et al. Science. 257: 1271–1273 (1992).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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