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Recombinant Synaptic Vesicle Protein 2 (SV2) (Marker of Neuroendocrine Cells) Antibody [r15E11]

Additional information

Catalog Number: 9900-MSM3
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
9900-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
9900-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
9900-MSM3-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Synaptic Vesicle Protein 2 Antibody in Immunohistochemistry (IHC (P))

Synaptic Vesicle Protein 2 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human testis stained with Synaptic Vesicle Protein 2 (SV2) Recombinant Mouse Monoclonal Antibody (r15E11). Inset: PBS instead of primary antibody; secondary only negative control.

Synaptic Vesicle Protein 2 Antibody in SDS-PAGE

Synaptic Vesicle Protein 2 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Synaptic Vesicle Protein 2 (SV2) Recombinant Mouse Monoclonal Antibody (r15E11). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
r15E11
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasmic vesicle, Secretory vesicle, Synaptic vesicle membrane, Presynapse
Gene Name
SV2A
Positive Control
Human brain.
Immunogen
Recombinant fragment corresponding to the n-terminal cytoplasmic domain of the human Synaptic Vesicle Protein 2 (SV2) protein
Expression System
CHO
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity)., (Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
9900
SwissProt
Q7L0J3
Chromosome Location
1q21.2
Mol. Weight of Antigen
82.69kDa
Alternate Names
Synaptic vesicle glycoprotein 2A, DEE113|SLC22B1|SV2

Summary

Synaptic vesicle protein 2 (SV2) is an integral membrane glycoprotein. It is required for normal neurotransmission and may play a role in the regulation of calcium-stimulated exocytosis. SV2 exists in three forms, SV2A, SV2B and SV2C, each containing 12 transmembrane spanning regions. SV2 proteins are among the most abundant and conserved components of synaptic vesicles in vertebrates. They are present on all small synaptic vesicles independent of transmitter type. SV2A and SV2B are widely distributed in the nervous system, whereas SV2C is only observed in a small number of neurons in a few areas of the brain. SV2A is expressed at the highest levels in subcortical regions, whereas the highest level of expression of SV2B is in the cortex and hippocampus. SV2 is expressed on secretory vesicles of neuroendocrine cells in the GI tract, pancreas, anterior pituitary gland, thyroid, parathyroid and adrenal medulla and also in exocrine chief cells of gastric mucosa.

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