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Recombinant MRP3 (Multidrug Resistance-Associated Protein 3) Antibody [rDTX1]

Additional information

Catalog Number: 8714-MSM5
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
8714-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
8714-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
8714-MSM5-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Multidrug Resistance-Associated Protein 3 Antibody in Immunohistochemistry (IHC (P))

Multidrug Resistance-Associated Protein 3 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human adrenal gland stained with MRP3 Recombinant Mouse Monoclonal Antibody (rDTX1). Inset: PBS instead of primary antibody; secondary only negative control.

MRP3 Antibody in SDS-PAGE

MRP3 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified MRP3 Recombinant Mouse Monoclonal Antibody (rDTX1). Confirmation of Purity and Integrity of Antibody.

MRP3 Antibody in Western Blot (WB)

MRP3 Antibody in Western Blot (WB)

Western Blot Analysis of PANC28 cell lysate using VEGFA Recombinant Mouse Monoclonal Antibody (rDTX1).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rDTX1
Isotype
IgG2a
Light Chain
Kappa
Cellular Localization
Basolateral cell membrane, Basal cell membrane
Gene Name
ABCC3
Positive Control
Human bowel, pancreas or adrenal gland. PANC28.
Immunogen
Recombinant fragment (around aa823-943) of the human Multidrug Resistance-Associated Protein 3 protein (exact sequence is proprietary)
Expression System
CHO
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
8714
SwissProt
O15438
Chromosome Location
17q21.33
Mol. Weight of Antigen
169.34kDa
Alternate Names
ATP-binding cassette sub-family C member 3, ABC31|EST90757|MLP2|MOAT-D|MRP3|cMOAT2

Summary

The human multidrug resistance-associated protein (MRP) gene family contains at least 6 members designated MRP-1 to 6. MRP3 is a 190 to 200 kD integral membrane protein which is an organic anion transporter effective in transporting chemotherapeutic drugs such as MTX, etoposide and teniposide. Northern blotting of various human tissues has indicated MRP3 to be expressed in liver, colon, pancreas and at lower levels in the kidney. In liver, MRP3 is localized to the basolateral membrane of hepatocytes and is not associated with the canalicular membrane. MRP3 is also thought to play a role in bile production and secretion in the liver.

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