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Recombinant Complement Component C9 (CCC9) (Early Myocardial Infarction Marker) Antibody [r10A6]

In Stock
Catalog Number Formulation Size Price
735-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
735-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
735-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Component C9 Antibody in Immunohistochemistry (IHC (P))

Component C9 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human tonsil stained with Complement Component C9 Recombinant Mouse Monoclonal Antibody (r10A6). Inset: PBS instead of primary antibody; secondary only negative control.

Component C9 Antibody in SDS-PAGE

Component C9 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Complement Component C9 Recombinant Mouse Monoclonal Antibody (r10A6). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Complement component C9 binds to the C5b-8 complex as the final protein of the membrane attack complex. After binding, it undergoes a conformational change and inserts itself into the cell membrane, forming transmembrane channels. Complement component C9 acts in a similar way
to perforin, a pore forming protein found in cytotoxic T cells. Male and female reproductive tissues express and synthesize complement components, binding proteins and receptors, although the implications of this are unclear.

Product Properties & Targets

Antibody Type
Mouse Monoclonals, Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Immunology, Complement System, Infectious Disease
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Secreted
Gene Name
C9
Positive Control
Human liver, placenta, myocardium or rejected renal transplant tissue.
Immunogen
Prokaryotic recombinant protein corresponding to a C-terminal region of the complement component C9 molecule.
Alternate Names
Complement component C9, C9, Complement component C9a | Complement component C9b

Database Links

Entrez Gene ID
735
SwissProt
P02748

Additional Information

Clone
r10A6
Chromosome Location
5p13.1
Mol. Weight of Antigen
71kDa
Expression System
CHO Cells

Related Antibodies

View All C9 Antibodies

Functions

  • Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells (PubMed:26841934, PubMed:9212048, PubMed:9634479). C9 is the pore-forming subunit of the MAC (PubMed:26841934, PubMed:30111885, PubMed:4055801).

Key References

  • Racusen LC et. al. Am J Transplant. 2003;3(6):708-14.
  • Ferreira, M A et al. “High prevalence of acute myocardial damage in a hospital necropsy series, shown by C9 immunohistology.” Journal of clinical pathology vol. 51,7 (1998): 548-51. doi:10.1136/jcp.51.7.548
  • Ratnoff, W D et al. “Immunohistochemical localization of C9 neoantigen and the terminal complement inhibitory protein CD59 in human endometrium.” American journal of reproductive immunology (New York, N.Y. : 1989) vol. 34,2 (1995): 72-9. doi:10.1111/j.1600-0897.1995.tb00921.x
  • Stanley, K K et al. “The sequence and topology of human complement component C9.” The EMBO journal vol. 4,2 (1985): 375-82. doi:10.1002/j.1460-2075.1985.tb03639.x

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in CHO cell mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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