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IDO2 / Indoleamine 2,3-dioxygenase 2 Antibody [IDO2/2639]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
169355-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
169355-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
169355-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG / Kappa
Gene Name
Positive Control
Human placenta or liver.
Immunogen
Recombinant fragment (around aa 200-350) of human IDO2 protein (exact sequence is proprietary)
Alternate Names
Indoleamine 2,3-dioxygenase 2, Indoleamine 2,3-dioxygenase-like protein 1, Indoleamine-pyrrole 2,3-dioxygenase-like protein 1, 3-dioxygenase 2; 3-dioxygenase-like protein 1; EC 1.13.11.; INDOL 1; Indoleamine 2; Indoleamine 2,3 dioxygenase 2; Indoleamine 2,3 dioxygenase like 1 protein; Indoleamine pyrrole 2,3 dioxygenase like 1; Indoleamine-pyrrole 2

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
IDO2/2639
Chromosome Location
8p11.21
Mol. Weight of Antigen
47kDa

Functions

  • Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).

Key References

  • Prendergast, GC et al. Cancer Res. 2017 Dec 15; 77(24): 6795 6811.

Storage & Stability

Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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