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Immunofluorescent staining of MeOH-fixed MCF-7 cells with HER-2 Monospecific Mouse Monoclonal Antibody (HRB2/451) followed by goat anti-Mouse IgG-CF488 (Green). Nuclei are stained with Reddot (Red).
Flow Cytometric Analysis of human trypsinized MCF-7 cells. HER-2 Monospecific Mouse Monoclonal Antibody (HRB2/451) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).
SDS-PAGE Analysis Purified HER-2 Monospecific Mouse Monoclonal Antibody (HRB2/451). Confirmation of Integrity and Purity of Antibody.
Flow Cytometric Analysis of human trypsinized SK-BR3 cells. HER-2 Monospecific Mouse Monoclonal Antibody (HRB2/451) followed by Goat anti-Mouse IgG-CF488 (Blue); Isotype control (Red).
Analysis of Protein Array containing more than 19,000 full-length human proteins using HER-2 Monospecific Mouse Monoclonal Antibody (HRB2/451) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD�s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD�s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
Immunofluorescent staining of PFA-fixed MCF-7 cells with HER-2 Monospecific Mouse Monoclonal Antibody (HRB2/451); followed by goat anti-mouse IgG-CF488 (Green). Nuclei are stained with Reddot (Red).
This MAb is specific to c-erbB-2/HER-2 and shows minimal cross-reaction with other members of the family. C-erbB-2/HER-2 is a member of the EGFR family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
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