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Recombinant D-Dimer / Fibrinogen gamma chain Antibody [FGG/13043R]

In Stock
Catalog Number Formulation Size Price
2266-RBM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
2266-RBM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
2266-RBM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Western Blot (WB)
2-4ug/ml

Summary

The plasma glycoprotein Fibrinogen is synthesized in the liver and comprises three structurally different subunits: a, b and g. Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i.e. the formation of Fibrin) and determination of plasma viscosity and erythrocyte aggregation. It is both constitutively expressed and inducible during an acute phase reaction. Hemostasis following tissue injury deploys essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade leading to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Following vascular injury, Fibrinogen is cleaved by Thrombin to form Fibrin, which is the most abundant component of blood clots. The cleavage products of Fibrinogen regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities and are mitogens for several cell types.
This antibody is directed against a neoantigenic determinant expressed on the human fragment D-dimer. D-dimer is a protein fragment (small piece) that’s made when a blood clot dissolves in your body. At D-dimer test is done to determine if a person has any blood clotting disorder.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Secreted
Gene Name
FGA
Positive Control
HepG2 or A-549 cells. Human kidney.
Immunogen
Recombinant human FGA protein (exact sequence is proprietary)
Alternate Names
fibrinogen gamma chain, Human FGG antibody Fibrinogen gamma chain antibody; Fibrinogen gamma polypeptide antibody; fibrinogen gamma-b chain antibody, fibrinogen; gamma polypeptide testicular tissue protein Li 70

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
FGG/13043R
Chromosome Location
4q31.3
Mol. Weight of Antigen
57kDa

Functions

  • Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Key References

  • Keam, S.P., et al. 2018. Exploring the oncoproteomic response of human prostate cancer to therapeutic radiation using data-independent acquisition (DIA) mass spectrometry. Prostate 78: 563-575.
  • Choi, J.W., et al. 2020. Proteome analysis of human natural killer cell derived extracellular vesicles for identification of anticancer effectors. Molecules 25: 5216

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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