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Decorin Antibody [DCN/3523]

In Stock
Best Seller
HuProt Validated
Catalog Number Formulation Size Price
1634-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1634-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1634-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGF尾 and is a direct or indirect negative modulator of TGF尾 synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-纬 and TNF伪 may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. The human Decorin gene maps to chromosome 12q21.33 and encodes a 359 amino acid protein.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Extracellular matrix, Extracellular space, Secreted
Gene Name
DCN
Positive Control
Human prostate or skin tissue (IHC).
Immunogen
Recombinant human Decorin protein fragment (aa212-336) (exact sequence is proprietary)
Alternate Names
Decorin, Bone proteoglycan II, PG-S2, PG40, Bone proteoglycan II; CSCD; Dermatan sulphate proteoglycans II (DSPG2); PG40; PGII; PGS2; Proteoglycan core protein; SLRR1B; Small leucine rich protein 1B

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
DCN/3523
Chromosome Location
12q21.3
Mol. Weight of Antigen
43kDa

Functions

  • May affect the rate of fibrils formation.

Key References

  • Krusius, T. and Ruoslahti, E. 1986. Proc. Natl. Acad. Sci. USA 83: 7683-7687.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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