| Catalog Number: | 1634-RBM7 |
|---|---|
| Gene: | |
| Host: | |
| Reactivity: |
Trial Size Available
Carrier-Free Available
Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Decorin Rabbit Recombinant Monoclonal Antibody (DCN/8715R). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.
SDS-PAGE Analysis of Purified Decorin Rabbit Recombinant Monoclonal Antibody (DCN/8715R). Confirmation of Purity and Integrity of Antibody.
Western Blot Analysis of Human Heart, Human Lung and Human Skeletal muscle tissue lysates using Decorin Recombinant Rabbit Monoclonal Antibody (DCN/8715R).
Western Blot Analysis of Heart and Lung tissue lysates of different species using Decorin Recombinant Rabbit Monoclonal Antibody (DCN/8715R).
| Document Name | |
|---|---|
| Datasheet | Download Here |
| Material Safety Data Sheet | Download Here |
| Applications | Tested Dilutions | Protocol | Note |
|---|---|---|---|
| Immunohistochemistry (IHC) | 1-2ug/ml | IHC Protocol | 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes |
| Western Blot (WB) | 2-4ug/ml | Western Blot Protocol |
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Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFβ and is a direct or indirect negative modulator of TGFβ synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-γ and TNFα may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.
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