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Recombinant Creatine Kinase MM (Biomarker for Muscular Injury & Cardiac Damage) Antibody [CKMM/13033R]

In Stock
Catalog Number Formulation Size Price
1158-RBM8-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$249.00
1158-RBM8-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$539.00
1158-RBM8-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$539.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Summary

Creatine kinases (CKs) are a large family of isoenzymes that regulate levels of ATP in subcellular compartments, where they provide ATP at sites of fluctuating energy demand by the transfer of phosphates between creatine and adenine nucleotides. Creatine kinases provide the energy of phosphate hydrolysis necessary to drive the normal function of many cellular systems including muscle, electrocytes, retina photoreceptor cells, brain cells, kidney, salt glands, myometrium, placenta, pancreas, thymus, thyroid, intestinal epithelial cells, endothelial cells, cartilage and bone cells, macrophages, blood platelets, and tumor and cancer cells. Human cytoplasmic creatine kinase-B, also designated CK-B and BCK, is a 381 amino acid, brain tissue-specific isoform of creatine kinase. Human cytoplasmic creatine kinase-M (CK-M, MCK) is a muscle tissue specific isoform of creatine kinase. Human cytoplasmic creatine kinase-Mi (Mi-CK, MtCK) is a 416 amino acid mitochondrial-specific isoform of creatine kinase. Cytosolic creatine kinases are important in the energetic regulation of Ca2+-pumps and in the maintenance of Ca2+-homeostasis.

The antibody binds specifically to the human creatine-kinase-MM subtype (and not the MB or BB subtype). This antibody binds to human muscle creatine-kinase-MM, an enzyme that catalyzes the conversion of creatine and ATP to phosphocreatine and ADP, generating an ATP-buffer in the muscle. The antibody blocks CK-MM activity by 80%.

Product Properties & Targets

Host
Rabbit
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cytoplasm
Gene Name
CKM
Positive Control
Human heart tissue. Skeletal muscle lysate.
Immunogen
Recombinant human CKM protein
Alternate Names
Creatine kinase M-type, Creatine kinase M chain, Creatine phosphokinase M-type, M-CK, CKM; CKMM; Creatine kinase M; Creatine kinase M chain; Creatine kinase M type; Creatine kinase M-type; Creatine kinase muscle; Creatine kinase, muscle type; M-CK; MCK; Muscle creatine kinase

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CKMM/13033R
Chromosome Location
19q13.32
Mol. Weight of Antigen
43kDa

Functions

  • Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Key References

  • Buckel et al. Cloning and nucleotide sequence of heavy- and light-chain cDNAs from a creatine-kinase specific monoclonal antibody Gene 1987; 51:13-19 PMID:3110009

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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