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Home >> Antibodies >> TCL1 (T-Cell Marker)

TCL1 (T-Cell Marker)

Mouse Monoclonal Antibody [Clone TCL1/2079]

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Catalog No Formulation Size Price (USD)  
8115-MSM2-P0 Purified Ab with BSA and Azide at 200ug/ml 20 ug 199.00
8115-MSM2-P1 Purified Ab with BSA and Azide at 200ug/ml 100 ug 429.00
8115-MSM2-P1ABX Purified Ab WITHOUT BSA and Azide at 1.0mg/ml 100 ug 429.00
Human Entrez Gene ID 8115
Human SwissProt P56279
Human Unigene 2484
Human Gene Symbol TCL1A
Human Chromosome Location 14q32.13
Synonyms TCL1A; Lymphoma/leukemia, T-cell; Oncogene TCL1; P14 TCL1; T cell leukemia 1; T cell lymphoma 1; T cell lymphoma 1A;T-cell leukemia/lymphoma 1A; TCL1; TCL1A
Immunogen Recombinant fragment (around aa 2-109) of human TCL1 protein (exact sequence is proprietary)
Host / Ig Isotype Mouse / IgG2a, kappa
Mol. Weight of Antigen 14kDa
Cellular Localization Nuclear and Cytoplasmic
Species Reactivity Human. Others not known.

Specificity & Comments

T-cell leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (TPLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.13. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma.

Known Applications & Suggested Dilutions

Western Blot ( 0.5-1ug/ml)
Immunohistology (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Positive Control

Ramos or Raji cells. Tonsil or T-cell Lymphoma.

Supplied As

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Storage and Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. ,Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

Key References

  1. Narducci MG, et al. Cancer Res. 2000; 60:2095-100.
  2. Roos J, et al. Pathobiology. 2001; 69:59-66.
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