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Home >> Antibodies >> TCL1 (T-Cell Marker)

TCL1 (T-Cell Marker)

Mouse Monoclonal Antibody [Clone TCL1/2079]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

199.00
429.00
429.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

199.00
429.00
429.00
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Formalin-fixed, paraffin-embedded human Tonsil stained with TCL1 Mouse Monoclonal Antibody (TCL1/2079).

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Formalin-fixed, paraffin-embedded human Lymph Node stained with TCL1 Mouse Monoclonal Antibody (TCL1/2079).

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Western Blot Analysis of Raji cell lysate using TCL1 Mouse Monoclonal Antibody (TCL1/2079).

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SDS-PAGE Analysis Purified TCL1 Mouse Monoclonal Antibody (TCL1/2079). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing more than 19,000 full-length human proteins using TCL1 Mouse Monoclonal Antibody (TCL1/2079).

Product Details

Synonyms

TCL1A; Lymphoma/leukemia, T-cell; Oncogene TCL1; P14 TCL1; T cell leukemia 1; T cell lymphoma 1; T cell lymphoma 1A; T-cell leukemia/lymphoma 1A; TCL1; TCL1A

Positive Control

Ramos or Raji cells. Tonsil or T-cell Lymphoma.

Known Applications & Suggested Dilutions

Western Blot, IHC-P         More Details

Western Blot (1-2ug/ml)
Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 2-109) of human TCL1 protein (exact sequence is proprietary)

Cellular Localization

Nuclear and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2a, kappa

Mol. Weight of Antigen

14kDa

Specificity & Comments

T-cell leukemia/Lymphoma Protein 1A (TCL-1A), also known as p14TCL1 is a product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (TPLL). T-PLL is a rare form of mature T-cell leukemia, which is consistently associated with chromosomal rearrangements characterized by the juxtaposition of the TCRA locus on chromosome 14q11 and the TCL1A gene on 14q32.13. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma.

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200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Narducci MG, et al. Cancer Res. 2000; 60:2095-100.
  2. Roos J, et al. Pathobiology. 2001; 69:59-66.

Bioinformatics

  •  Entrez Gene ID: 10232
  •  Gene Symbol: TCL1A
  •  SwissProt: P56279
  •  Chromosome Location: 14q32.13
  •  Unigene: 2484
NBT02079